Saint Joseph (informally, St. Joe) is the largest city in Northwest Missouri, serving as the county seat for Buchanan County. With a 2008 estimated population of 76,197, Saint Joseph is the eighth largest city in the state. The St. Joseph Metropolitan Statistical Area, which includes Buchanan, Andrew, and DeKalb counties in Missouri and Doniphan County, Kansas, had an estimated population of 122,306 in 2006. Saint Joseph is also home to Missouri Western State University.